Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease

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[Differential diagnosis of corticobasal syndrome (CBS) and its biomarkers].

Corticobasal degeneration (CBD) was initially thought to represent a clinicopathological entity, but recent studies have shown its considerable clinicopathological heterogeneity. Thus, the constellation of the findings initially considered characteristic of CBD is now named "corticobasal syndrome" (CBS), while the term "CBD" is used for the histopathological disorder. Multiple phenotypes associ...

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Ganser symptoms in a Chinese speaking corticobasal syndrome (CBS) patient.

Dear Editor, Ganser syndrome was fi rst described by Sigbert Ganser in 1897, characterised by approximate answers to real questions, dulling of consciousness, hysterical neurological changes and hallucinations.1-3 Ganser syndrome was mainly considered as a psychiatric illness, based on the theory that Ganser syndrome represents a means of coping with stress in those who are intellectually compr...

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COTS-Based Systems (CBS) Functional Density -- A Heuristic for Better CBS Design

The conventional rationale for using COTS (commercial offthe-shelf) components is that the more a software system is built from COTS products, the lower the cost of initial development. Less understood is that during the long term sustainment phase – from deployment through retirement – the cost of maintenance of a COTS-based system generally increases as the number of COTS products used increa...

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Dopamine Transporter SPECT Imaging in Corticobasal Syndrome

OBJECTIVE To investigate dopaminergic function in a large cohort of patients with corticobasal syndrome (CBS) and describe its relationship with clinical features in comparison to Parkinson's disease and healthy control subjects. In addition, we assessed prevalence and features of individuals with CBS and in vivo evidence of preserved nigral neuronal density. BACKGROUND Substantia nigra pars ...

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Rescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymes.

Missense mutations represent the most common cause of many genetic diseases including cystathionine beta-synthase (CBS) deficiency. Many of these mutations result in misfolded proteins, which lack biological function. The presence of chemical chaperones can sometimes alleviate or even restore protein folding and activity of mutant proteins. We present the purification and characterization of ei...

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ژورنال

عنوان ژورنال: Movement Disorders

سال: 2010

ISSN: 0885-3185

DOI: 10.1002/mds.23062